Provided are a nutritional supplement composition including effective amounts of Coenzyme Q10, fish oil, vitamin D and a pharmaceutically acceptable excipient and a method of promoting nutritional health comprising administering a nutritional supplement of the present invention. The nutritional supplement composition may further include flax seed oil, borage oil, evening primrose oil, vitamin E, resveratrol, vitamin B6, vitamin B12, folic acid, piperine and combinations thereof. Administering the nutritional supplement to a subject may ameliorate nutrient depletion, or promote cardiovascular health, liver health, or both； as well as ameliorate nutrient depletion in a subject taking a cholesterol lowering drug such as statin.
