The invention provides a method for treating cancers including hematologic malignancies comprising administering a compound of Formula I: in combination with one or both of bendamustine and rituximab.本發明提供一種治療包括惡性血液疾病之癌症之方法,包括與苯達莫司汀及利妥昔單抗中之一或兩者組合投與式I化合物: