McDermott, Martina,Roninson, Igor B.,Broude, Eugenia
申请号：
AU2015296968
公开号：
AU2015296968A1
申请日:
2015.06.10
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
Cancers that overexpress tyrosine kinase receptors of HER family are treated with drugs acting on these receptors. Although HER-targeting drugs have revolutionized the treatment of HER-positive cancers, high rates of primary and treatment-emergent resistance limit their clinical utility. The present inventors have now discovered that combining HER-targeting drugs with a selective inhibitor of CDK8/19 greatly improves the efficacy of such drugs, offering an improved approach to the treatment of HER-positive cancers.
