DOWNHAM, ROBERT,SIBLEY, GRAHAM EDWARD MORRIS,PAYNE, LLOYD JAMES,EDWARDS, PHILIP,DAVIES, GARETH MORSE
申请号：
ES07824661
公开号：
ES2451659T3
申请日:
2007.11.21
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound that is an indolizinyl derivative of formula (I), or a pharmaceutically acceptable salt thereof: ** Formula ** where: X is a bond, -NR8-, -O-, -S-, -SO- or - SO2-； 10 X1 is O or NOR9, where R9 is hydrogen or an unsubstituted or substituted C1-C4 alkyl group； R1 represents -A3-L3-A4, -A3-L1- (A4) p- (A11) q-L3-A5, -A6-L1-A7, -A3-L4-A8, -A3-W, -A9, -A3-L1-A9 or -A10, where p and q are the same or different and represent zero or 1； R8 represents hydrogen, or an unsubstituted or substituted group selected from C6-C10 aryl, a 5-12 membered heterocyclyl group, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C6 cycloalkyl, -A1-L1 -A2, -L2-A2, -COR 'and -YZ； L1 is a bond, -NR'-, -O-, -CO-, -OCO-, -OCONR'R '' or -CONR'R '' -； L2 is a C1-C4 alkylene or C2-C4 alkenylene group unsubstituted or substituted； L3 is a bond or group of the formula - (Het) r-Alq1- (Het) s-, - (Alq2) mC (>； = O) -Het- (Alq3) n-, -Alq4- or -SO2-, where Alq1, Alq2, Alq3 and Alq4 are the same or different and represent unsubstituted C1-C4 alkylene groups, m, n, sonysual or different rys and represent zero or 1, and Het represents -O- or -NR9-, where R9 is hydrogen or unsubstituted C1-C4 alkyl； L4 is an imino group -N>； =, where the double bond is linked to group A8； A1 is an unsubstituted or substituted C6-C10 arylene group； A2, A3, A4, A5, A7 and A11 are the same or different and are unsubstituted or substituted C6-C10 aryl or heterocyclyl groups of 5 to 12 members； A6 is a C6-C10 aryl or a 5 to 12 membered heterocyclyl group that is substituted with at least one C6-C10 aryl or a 5 to 12 membered heterocyclyl group that is unsubstituted or substituted； A8 is an unsubstituted or substituted 5 to 12 membered heterocyclyl group； A9 is a 5- to 12-membered unsubstituted or substituted heterocyclyl group where 1 or 2 carbon atoms in the ring are replaced by a group selected from>； C (>； = O),>； S (>； = O) 2,>； C ( >； = NOR11), where R11 is hydrogen or a C1-C4 alkyl group,>； C>； =
