Provided herein are methods that relate to a therapeutic strategy for treatment of cancer, and allergic, autoimmune, and inflammatory disorders including hematological malignancies. In particular, the methods include administration of a BTK inhibitor and with one or more inhibitor. For example, the one or more inhibitor may be a JAK inhibitor, a ASK1 inhibitor, a BRD4 inhibitor or an MMP9 inhibitor.本文所提供之方法係關於治療癌症及過敏性、自體免疫及發炎病症(包括血液惡性病)之治療策略。具體而言,該等方法包括投與BTK抑制劑及一或多種抑制劑。舉例而言,該一或多種抑制劑可為JAK抑制劑、ASK1抑制劑、BRD4抑制劑或MMP9抑制劑。