Problem to be solved: to provide a pharmaceutical composition containing a bicyclic compound compound which is an inhibitor of FGFR4 enzyme and is useful in treating FGFR4 related diseases such as cancer.Solution: a bicyclic complex of N - [2 -] - (2,6-difluoro-3,5-dimethoxyphenyl) - 3 - oxo-2 ', 3 - dihydro-1' h-spiro [cyclopropane-1,4 - [[2,7] naphthyridine] - 6] - YL] methyl} acrylamide Combination medicine containing ring compound and further therapeutic agent.No selection【課題】ＦＧＦＲ４酵素の阻害剤であり、癌等のＦＧＦＲ４関連疾患の治療に有用な、二環式複素環化合物を含む医薬組成物の提供。【解決手段】Ｎ－｛［２’－（２，６－ジフルオロ－３，５－ジメトキシフェニル）－３’－オキソ－２’，３’－ジヒドロ－１’Ｈ－スピロ［シクロプロパン－１，４’－［２，７］ナフチリジン］－６’－イル］メチル｝アクリルアミドなどの二環式複素環化合物と、さらなる治療剤とを含む組合せ医薬。【選択図】なし
