WALLACE, SHELLEY L.,TAYLOR, AMANDA F.,CHARLEBOIS, STEVEN,STEINHART, CHRISTINE M.,FEARNOT, NEAL E.
申请号：
CA2923002
公开号：
CA2923002A1
申请日:
2014.09.02
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Osteogenic compositions include a decellularized extracellular matrix tissue and bone morphogenic protein, preferably BMP-2. The compositions make beneficial use of the BMP, which can be used at relatively low doses and can bind to native components (e.g., native sulfated glycosaminoglycans such as heparin and/or heparan sulfate) remaining in the decellularized extracellular matrix tissue. Methods for preparation and use of such compositions are also described. The compositions and related methods can be used in the treatment of diseased or damaged bone tissue.
