INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE);UNIVERSITÉ PARIS DESCARTES;ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP);UNIVERSITÉ PARIS DIDEROT - PARIS 7
发明人:
RAUTOU, Pierre-Emmanuel,BOULANGER-ROBERT, Chantal
申请号：
WO2017EP76005
公开号：
WO2018069422(A1)
申请日:
2017.10.12
申请国别(地区):
世界知识产权组织国际局
年份:
2018
代理人:
摘要：
The present invention relates to methods and pharmaceutical compositions for the treatment of non-alcoholic fatty liver disease. The inventors showed that autophagy is defective in liver sinusoidal endothelial cells (LSECs) from patients with non-alcoholic steatohepatitis (NASH) and contributes to the main features of this disease. In particular, the present invention relates to a method of treating a non-alcoholic fatty liver disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an agent capable of restoring autophagy in the subject's liver sinusoidal endothelial cells.
