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FORME CRISTALLINE A DE NICOTINATE D'INOSITOL ET PROCÉDÉ DE PRÉPARATION DE CELLE-CI
专利权人:
Ltd.;Weifang Shengyu Pharma Co.
发明人:
申请号:
EP16848122.4
公开号:
EP3354642A4
申请日:
2016.09.21
申请国别(地区):
EP
年份:
2019
代理人:
摘要:
Provided are an inositol nicotinate crystalline form A and a preparation method therefor. The X-ray powder diffraction analysis, obtained by using Cu-K± ray measurement, of the inositol nicotinate crystalline form A has obvious characteristic diffraction peaks at least at 2¸ values, expressed in degrees, of 7.05, 7.41, 9.74, 17.80, 19.86, 23.57, 25.48 and 26.20 with an error range of +/-0.2°. The preparation method is one of or a mixed crystallization method of two or more of an evaporation crystallization method, a cooling crystallization method or an anti-solvent crystallization method. The process thereof is simple and easy to operate, and has more selectivity; the inositol nicotinate crystalline form A can be prepared by various methods, and the prepared product has a good crystallization degree and high chemical stability; and the inositol nicotinate crystalline form A prepared by the present method does not have the problem that a residual solvent is out-of-limit.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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