The disclosure provides local delivery of a trace element to a site of tissue injury, which triggers the body' inherent tissue repair mechanism. Local delivery of copper to the site of injury induces migration (i.e., homing) of stem cells to the site of injury, triggers differentiation of stem cells at the site of injury, induces tissue regeneration at the site of injury, induces signaling molecules that trigger tissue regeneration, reverses damage at the site of injury, and/or reconstructs the microenvironment of neurofibril cells and neurosecretory cells at the site of injury. In another aspect, delivering a trace element (for example, copper) directly to the site of injury and associated methods are disclosed.本發明關於將微量元素局部遞送至組織損傷部位，其觸發個體的固有組織修復機制。將銅局部遞送至損傷部位誘導幹細胞向損傷部位遷移(亦即，歸巢)，觸發幹細胞在損傷部位分化，誘導損傷部位發生組織再生，誘導觸發組織再生的訊號傳導分子，逆轉損傷部位的損傷及/或在損傷部位重建神經原纖維細胞和神經分泌細胞的微環境。在另一個方面，揭露將微量元素(例如，銅)直接遞送至損傷部位及相關方法。
