UTILISATION DE LA MÉTFORMINE EN ASSOCIATION AVEC UN ACTIVATEUR DE LA GLUCOKINASE ET COMPOSITIONS COMPRENANT LA MÉTFORMINE ET UN ACTIVATEUR DE LA GLUCOKINASE
The present invention provides uses of a glucokinase activator in combination with metformin. Uses include treating type 2 diabetes, lowering blood glucose, improving insulin sensitivity, enhancing phosphorylation of glucose, and improving the therapeutic effectiveness of metformin. The invention also provides pharmaceutical compositions that comprise a GK activator and metformin. The invention also provides a salt formed between metformin and a GK activator.