OELKE, MATHIAS,SANTOS, JOSE LUIS,KIM, SOJUNG,SCHNECK, JONATHAN,KOSMIDES, ALYSSA
申请号：
CA3017615
公开号：
CA3017615A1
申请日:
2017.03.16
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The invention in various aspects provides for magnetic enrichment and/or expansion of antigen-specific T cells, allowing for identification and characterization of antigen-specific T cells and their T cell receptors (TCRs) for therapeutic and/or diagnostic purposes, as well as providing for production of antigen-specific engineered T cells for therapy. Incubation of paramagnetic nano-aAPCs in the presence of a magnetic field, either during enrichment and/or expansion steps, activates T cells through magnetic clustering of paramagnetic particles on the T cell surface.
