Abstract: This invention provides long-acting, superactive analogs of glycoprotein hormones demonstrating enhanced bioactivity both in vitro and in vivo as compared to wild type counterparts. the analogs are particularly useful for treating subjects showing low receptor expression or poor receptor responsiveness, and for the treatment of any condition associated with glycoprotein hormone activity. abstract of patent summary: "long acting super agonists of hormone glycoprotein". The present invention provides long-acting superactive analogs of glycoprotein hormones demonstrating improved bioactivity in both in vitro and in vivo as compared to wild-type counterparts. The analogs are particularly useful for treating subjects showing low receptor expression or poor receptor responsiveness, and for treating any condition associated with hormone glycoprotein activity.abstract: this invention provides long-acting, superactive analogs of glycoprotein hormones demonstrating enhanced bioactivity both in vitro and in vivo as compared to wild type counterparts. the analogs are particularly useful for treating subjects showing low receptor expression or poor receptor responsiveness, and for the treatment of any condition associated with glycoprotein hormone activity. tradução do resumo resumo patente de invenção: "super agonistas de ação longa de hormônio glicoproteína". a presente invenção provê análogos superativos, de ação longa, de hormônios glicoproteínas demonstrando aperfeiçoada bioatividade em ambos, in vitro e in vivo como comparados a contrapartes tipo selvagem. os análogos são particularmente úteis para tratamento de sujeitos mostrando baixa expressão de receptor ou pobre capacidade de resposta de receptor, e para o tratamento de qualquer condição associada com atividade de hormônio glicoproteína.
