The present invention relates to pharmaceutical compositions comprising a quinolone carboxylic acid derivative antimicrobial agent and an effervescent agent. These compositions have improved gastrointestinal tolerability and/or reduced potential to cause gastrointestinal side effects. These compositions are useful for oral administration, for treating, preventing, or reducing the risk of microbial infections.本發明是關於醫藥組成物,其包括喹諾酮羧酸衍生之抗微生物劑及發泡劑。這些組成物具有改良的胃腸耐受性及/或引起胃腸副作用的可能性降低。這些組成物適用於經口投與以治療、預防微生物感染或降低其風險。