A novel compound able to inhibit JAK is disclosed,(see formula)This compound may be prepared as a pharmaceutical composition, and may beuseful for the prevention and treatment of a variety of conditions in mammalsincluding humans,such as, inflammatory conditions, autoimmune diseases, proliferative diseases,transplantationrejection, diseases involving impairment of cartilage turnover, congenitalcartilage malformations,and/or diseases associated with hypersecretion of IL6.