Compositions of rAAV vectors that have tyrosine modified capsid proteins and methods for their use

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专利权人:

University of Florida Research Foundation; Inc.

发明人:

ZHONG, Li,ZOLOTUKHIN, Sergei,GOVINDASAMY, Lakshmanan,AGBANDJE-MCKENNA, Mavis,SRIVASTAVA, Arun

申请号：

ES08733161

公开号：

ES2599632T3

申请日:

2008.04.08

申请国别(地区):

ES

年份:

2017

代理人:

摘要：

An recombinant serotype 2 adeno-associated viral vector (rAAV2) comprising at least one tyrosine residue exposed on the mutated surface on its capsid protein, the at least one mutated tyrosine residue selected from the group consisting of Tyr252, Tyr272 , Tyr444, Tyr500, Tyr700, Tyr704, Tyr730, Tyr275, Tyr281, Tyr508, Tyr576, Tyr612, Tyr673 or Tyr720.Un vector viral adeno-asociado de serotipo 2 recombinante (rAAV2) que comprende al menos un resto de tirosina expuesto en la superficie mutado sobre su proteína de la cápside, el al menos un resto de tirosina mutado seleccionado del grupo que consiste en Tyr252, Tyr272, Tyr444, Tyr500, Tyr700, Tyr704, Tyr730, Tyr275, Tyr281, Tyr508, Tyr576, Tyr612, Tyr673 o Tyr720.

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中国工程科技知识中心

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