Extracellular contrast agent (ECCM) for the diagnosis of lesions in combination/conjunction with a lesion-specific contrast agent (LSCM), is claimed. Independent claims are included for: (1) an application device for the combined application of ECCM for the diagnosis of lesions in combination/conjunction with LSCM, where the application device allows separate recording and application of the ECCM and the LSCM； and (2) a method for the diagnosis of lesions, where, ECCM is administered in combination/conjunction with LSCM and, preferably, the interpolation of the imaging signals occurs immediately.
