Compositions containing about 0.2% to about 20% of tea tree oil are described.Some compositions are in the formof solutions, suspensions, spray, lotions, gels, pastes, medicated sticks,balms, cleansers (including shampoos and soaps), creams,or ointments. Also described are compositions and methods for use in treatingocular Demodex infestations and related conditionsusing such compositions.