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OWN MAGNETIC HYDROXYAPATITIS
专利权人:
КОНСИЛИО НАЦИОНАЛЕ ДЕЛЛЕ РИЧЕРКЕ (IT);ФИН-КЕРАМИКА ФАЭНЦА С.П.А. (IT)
发明人:
ТАМПИЕРИ Анна (IT),ЛАНДИ Элена (IT),САНДРИ Моника (IT),ПРЕССАТО Даниеле (IT),РИВАС РЕЙ Хосе (ES),БАНОБРЕ ЛОПЕС Мануэль (ES),МАРКАЧЧИ Маурилио (IT)
申请号:
RU2013109226/15
公开号:
RU2013109226A
申请日:
2011.07.28
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. Hydroxyapatite containing calcium ions and phosphate ions in the crystal lattice, characterized in that it is doped with Fe ions and Fe ions, which partially replace the specified calcium ions in the specified crystal lattice, in a quantitative ratio of Fe / Fe from 1 to 4, has a magnetization of 0.05 to 8 emu / g, measured in an applied 34E magnetic field, due to the presence of magnetic nanodomains in the hydroxyapatite lattice, and contains secondary magnetic phases in an amount of less than about 3 vol.%. 2. Hydroxyapatite according to claim 1, where the specified magnetization recorded in the applied magnetic field 34E, is from 0.1 to 5 eme / g. Hydroxyapatite according to claim 1, where the specified ratio of Fe / Fe is from 2 to 3.5.4. Hydroxyapatite according to claim 1, containing secondary magnetic phases in an amount of ≤2 vol.%. Hydroxyapatite according to claim 1, having a ratio (Fe + Ca) / P of from 1.5 to 1.9.6. Hydroxyapatite according to claim 1 in the form of nanoparticles having a width of 5-10 nm to 20-30 nm and a length of up to 80-150 nm, or in the form of aggregates / granules of said nanoparticles. Hydroxyapatite according to claim 6, where these nanoparticles contain spherical voids of 2-5 nm. Hydroxyapatite according to claim 1, loaded with biological substances selected from the group consisting of proteins, genes, stem cells, growth factors and vascularization factors, or loaded with active substances or drugs. A biomimetic substitute for bone or bone-cartilage tissue containing hydroxyapatite according to claim 1.10. Hydroxyapatite according to claim 1 or a biomimetic substitute for bone or bone-cartilage tissue according to claim 9 for medical or diagnostic use. Hydroxyapatite according to claim 10 for use as a means of delivery and1. Гидроксиапатит, содержащий ионы кальция и фосфат-ионы в кристаллической решетке, отличающийся тем, что он легирован ионами Feи ионами Fe, которые частично замещают указанные ионы кальция в указанной кри
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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