Process For The Conjugation Of A Peptide Or Protein With A Reagent Comprising A Leaving Group Including A Portion Of PEG

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专利权人:

发明人:

Antony Godwin,George Badescu,Matthew Bird,Penny Bryant,David Morris,Mark Frigerio

申请号：

US15517971

公开号：

US20170304461A1

申请日:

2015.10.08

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The invention relates to novel conjugating reagents capable of reaction with at least one nucleophile present in a peptide or protein, which contain at least one leaving group which is lost on reaction with said nucleophile, in which the leaving group includes a portion —(CH2CH2O)n—, in which n is a number of six or more and novel processes for the preparation of conjugates containing peptides or proteins made using such reagents.

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