NANOVÉHICULES ENDOPLASMIQUES CIBLANT LE RÉTICULUM

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专利权人:

National Cheng Kung University

发明人:

申请号：

EP19156311.3

公开号：

EP3549580A2

申请日:

2019.02.08

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

The invention relates to a composition comprising a sarcoplasmic/endoplasmic reticulum calcium ATPase pump inhibitor encapsulated in a polymer nanoparticle, for use in treating a disease caused by protein retention in the endoplasmic reticulum (ER). Further provided is a transgenic mouse carrying in its genome a heterologous nucleic acid that encodes an H338Y mutant gp91phox protein. The transgenic mouse can serve as a model for human chronic granulomatous disease.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/