Maria Mendez-Perez,Kristin Breitschopf,Katrin Lorenz,Hartmut Strobel,Li-hsing Wang,Alexander Schiffer,Jochen Goerlitzer
申请号：
US15100608
公开号：
US09776991B2
申请日:
2014.12.02
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to compounds of the formula (I), wherein R1, R2, R3, R4 and X have the meanings indicated in the claims. The compounds of formula I are valuable pharmacologically active compounds. They are highly potent and selective soluble epoxide hydrolase inhibitors and are suitable, for example, for the therapy and prophylaxis of renal failure, diabetic nephropathy, type 2 diabetes mellitus, cardiovascular diseases, inflammatory diseases or could show beneficial effects in pain, dyslipidemia, atherosclerosis wound healing and stroke. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
