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CHIMERIC FIBROBLAST GROWTH FACTOR 23 PROTEINS AND METHODS OF USE
专利权人:
发明人:
Moosa MOHAMMADI,Regina GOETZ
申请号:
US15598420
公开号:
US20170355738A1
申请日:
2017.05.18
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention relates to a chimeric protein that includes an N-terminus coupled to a C-terminus, where the N-terminus includes a portion of a paracrine fibroblast growth factor (“FGF”) and the C-terminus includes a C-terminal portion of an FGF23 molecule. The portion of the paracrine FGF is modified to decrease binding affinity for heparin and/or heparan sulfate compared to the portion without the modification. The present invention also relates to pharmaceutical compositions including chimeric proteins according to the present invention, methods for treating a subject suffering from a disorder, and methods of screening for compounds with enhanced binding affinity for the αKlotho-FGF receptor complex involving the use of chimeric proteins of the present invention.
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