In various embodiments, provided herein are devices, systems and methods using two, three or more pigtails for precisely imaging an aortic valve complex with minimal contrast and/or for advancing an instrument, such as a wire, or device, such as a transcatheter valve, across an aortic valve. In various embodiments, these devices, systems and methods may be used to diagnose and/or treat patients with aortic stenosis, other valvular heart disease or other cardiovascular or non cardiovascular disease, facilitating precise contrast or drug or device delivery, precise pressure measurement and/or precise drainage or sampling. In some embodiments, each of the multiple pigtails of the device may be advanced independently of one another in multiple directions and at multiple lengths of deployment to optimize position.
