BLAKE JAMES F,DELISLE ROBERT KIRK,DE MEESE LISA A.,GRAHAM JAMES M.,LE HUEROU YVAN,LYON MICHAEL,ROBINSON JOHN E.,WALLACE ELI M.,WANG BIN,XU RUI
申请号：
NZ61530012
公开号：
NZ615300A
申请日:
2012.02.24
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
This disclosure relates to a family of triazolopyridine compounds of general formula I, wherein R1, R2, R3, R4 and R10 are as disclosed in the specification. Their use as PIM kinase inhibitors are also disclosed, including their use for treating inflammatory or autoimmune disorders. Example compounds include: (S)-1-((R)-2,2,2-trifluoro-1-(3-(6-fluoro-7-((R)-2-methoxypropoxy)quinolin-2-yl)[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-amine di-hydrochloride 2-(2-(6-((S)-1-((S)-3-amino-3-methylpyrrolidin-1-yl)-2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-7-yl)ethanol (S)-3-methyl-1-((S)-2,2,2-trifluoro-1-(3-(7-((S)-2-methoxypropoxy)quinolin-2-yl)[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-amine (S)-1-((R)-2,2,2-trifluoro-1-(3-(7-((R)-2-methoxypropoxy)quinolin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)ethyl)pyrrolidin-3-amine dihydrochloride (S)-1-((S)-1-(3-(7-ethoxy-6-fluoroquinolin-2-yl)-[1,24]triazolo[4,3-alpyridin-6-yl)-2,2,2-trifluoroethyl)pyrrolidin-3-amine dihydrochloride
