HIEBERT, Sheldon,RAJAMANI, Ramkumar,SUN, Li-Qiang,MULL, Eric,GILLIS, Eric P.,BOWSHER, Michael S.,ZHAO, Qian,MEANWELL, Nicholas A.,RENDUCHINTALA, Kishore V.,SARKUNAM, Kandhasamy,NAGALAKSHMI, Pulicharla
申请号：
ES12723993
公开号：
ES2610967T3
申请日:
2012.05.01
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, wherein p is 1 or 2； ---- is a single or double bond； R1 is selected from ** Formula ** in which R1 binds to the rest of the parental molecule through any substitutable carbon atom in the group； m is 0, 1 or 2； n is 0, 1, 2, 3, 4, 5 or 6； X0 is selected from CH and N； X1 is selected from CH and N； X2 and X3 are independently selected from CH, C (Ra) and N； with the proviso that at least one of X1, X2 and X3 is different from N； Each Ra, alkoxy, alkoxyalkoxy, alkyl, benzodioxanyl, carboxamido, carboxy, carboalkoxy, cyano, cycloalkylalkoxy, cycloalkyloxy, deuteroalcoxi, dialkylamino, halo, haloalkyl, haloalkoxy, haloalkoxycarbonyl, hydroxy, morpholinyl, phenyl, is independently selected from alkenyloxy piperazinyl, pyrazolyl and pyridinyl, pyrrolidinyl, wherein morpholinyl, phenyl, piprazinyl, pyridinyl and pyrrolidinyl are optionally substituted with one or two groups independently selected from alkoxy, alkyl, alkylsulfonyl, halo, haloalkoxy, haloalkyl and morpholinyl； and wherein two adjacent Ra groups, together with the carbon atoms to which they are attached, can optionally form a ring selected from dioxanyl, dioxolanyl, morpholinyl, pyranyl and phenyl, wherein the ring is optionally substituted with one or two groups independently selected from alkyl and halo； Rb is alkyl； Rx is selected from methyl and ethyl； Ry and Rz are independently selected from hydrogen and hydroxy； with the proviso that when ---- it is a double bond, Ry and Rz are each hydrogen； R2 is selected from hydrogen, alkyl, halo, haloalkoxy, haloalkyl and hydroxyalkyl； and R3 is selected from hydrogen, alkoxyalkoxycarbonyl, alkoxycarbonyl, alkylaminocarbonyl, alkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylcarbonyl, cycloalkyloxycarbonyl, deuteroalcoxicarbonilo, deuterohaloalcoxicarbonilo, dialkylaminocarbonyl, dialquilaminocarbonilcarbonilo, haloalkoxycarbonyl, haloalquilaminocarbonilo, haloalkylcarbonyl, h
