A skull endosseous module for ultrasound penetration is provided and includes a fixation sleeve permanently inserted and positioned in a drilled hole of a skull, a movable sleeve movably inserted in the fixation sleeve for providing a hollow ultrasound guiding channel and an outer cover mounted on an outer opening of the fixation sleeve and covered by a scalp tissue. Thus, an ultrasound device outside the scalp tissue can generate ultrasounds to pass through the outer cover and the ultrasound guiding channel for affecting a target region of a brain tissue in the skull.
