Maria MENDEZ PEREZ,Nils RACKELMANN,Laurent BIALY,Stefan GUESSREGEN,Martin WILL,Thomas BOEHME,Ana VILLAR GAREA,Marcus Hermann KORN,Melissa BESENIUS,Jens RIEDEL,Ulrich WERNER,Michael PODESCHWA
申请号：
US16709208
公开号：
US20200181223A1
申请日:
2019.12.10
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.
