Protection of cells from Alu-RNA-induced degeneration and inhibitors for protecting cells

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专利权人:

UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION

发明人:

Jayakrishna Ambati,Valeria Tarallo

申请号：

US14158357

公开号：

US09453226B2

申请日:

2014.01.17

申请国别(地区):

US

年份:

2016

代理人:

摘要：

A method of protecting a cell includes inhibiting an inflammasome, MyD88, IL-18, VDAC1, VDAC2, caspase-8, and/or NFκB of the cell. Administering an inhibitor of MyD88, IL-18, VDAC1, VDAC2, caspase-8, and/or NFκB can protect the cell from Alu-RNA-induced degeneration. Protecting a cell, such as an retinal pigment epithelium (RPE), can be therapeutically useful in the context of age-related macular degeneration and geographic atrophy.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/