Novel carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids

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专利权人:

Inc.;Acuitas Therapeutics

发明人:

Du, Xinyao,Ansell, Steven M.

申请号：

AU2018256877

公开号：

AU2018256877A1

申请日:

2018.04.27

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

Compounds are provided having one of the the following structures (I) or (II): or (I) (II) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R3a, R3b, L1, L2, G1a, G1b, G2a, G2b and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

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中国工程科技知识中心

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