Seehra, Jasbir,Kumar, Ravindra,Lachey, Jennifer,Koncarevic, Alan
申请号：
AU2016200913
公开号：
AU2016200913A1
申请日:
2016.02.12
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016200913A120160303.pdf#####METHODS FOR INCREASING ADIPONECTIN ABSTRACT In certain aspects, the present invention provides compositions and methods for increasing adiponectin in a patient in need thereof by administering an antagonist of an ActRIIB signaling pathway. Examples of such antagonists include ActRIIB polypeptides, anti-ActRIIB antibodies, anti-activin A and/or B antibodies, anti-myostatin antibodies, antiGDF3 antibodies, and anti-BMP7 antibodies. Also provided are methods for ameliorating one or more undesired effects of anti-androgen therapy, including muscle loss, bone loss, increased adiposity, and/or increased insulin resistance. A variety of disorders may be treated by causing an increase in circulating adiponectin concentrations.
