COMBINATION OF AN ANTIBODIUM FUSED PROTEIN AGAINST EDB FIBRONECTIN-IL-2 AND THE MOLECULE BINDING WITH B-CELLS, B-CELL PREDATORS AND / OR THEIR MALIGNANT ANALOGUE
1. A combination containing at least! i) a fusion protein containing an antibody part specifically recognizing EDb-fibronectin and an interleukin-2 part and! ii) a molecule that binds to B cells, precursors of B cells and / or their malignant analogue； or a fusion protein comprising an antibody part specifically recognizing EDb-fibronectin and an interleukin-2 part and a molecule specifically binding to CD20； or ! iii) a fusion protein containing an antibody part specifically recognizing EDb-fibronectin and an interleukin-2 part and a molecule specifically binding to cells expressing CD20. ! 2. The combination according to claim 1, in which the molecule binds to B cells, precursors of B cells and / or their malignant analogue, specifically binds to CD20, CD23, CD22, CD40, CD80, HLA-DR or Hu1D10. ! 3. The combination according to claim 2, in which the molecule specifically binding to CD20, CD23, CD22, CD40 or CD80, is an antibody or antibody fragment or their fusion protein. ! 4. The combination according to claim 1, wherein the fusion protein has a fusion protein linker connecting the antibody part and the interleukin-2 part. !5. The combination according to claim 1, in which the part of the antibody specifically binds to the EDb domain of oncoembryonic fibronectin with subnanomolar or nanomolar affinity. ! 6. The combination according to claim 1, in which the part of the antibody contains at least one CDR sequence of the antibody L19. ! 7. The combination according to claim 1, in which the part of the antibody contains the sequence according to SEQ ID NO: 6-11. ! 8. The combination according to claim 1, in which the part of the antibody contains at least one heavy chain V according to SEQ ID NO: 1 or at least one light chain V according to SEQ ID NO: 2.! 9. The combination according to claim 1, in which the part is anti1. Комбинация, содержащая по меньшей мере ! i) слитый белок, содержащий часть-антитело, специфически распознающую EDb-фибронектин, и часть-интерлей
