PROBLEM TO BE SOLVED: To provide a variant type ASXL1 knock-in mouse capable of becoming a model mouse in a precancerous state of a myeloid tumor.SOLUTION: In a knock-in mouse, a variant type ASXL1 gene of a mouse, which imitates an ASXL1 mutant gene observed in a human myelodysplastic syndrome (MDS) patient, is knocked in, and the gene is specifically developed in hematopoietic cells.SELECTED DRAWING: NoneCOPYRIGHT: (C)2019,JPO&INPIT【課題】ミエロイド系腫瘍の前癌状態のモデルマウスとなり得る変異型ASXL1ノックインマウスの提供。【解決手段】ヒトの骨髄異形成症候群(MDS)患者において認められるASXL1変異遺伝子を模倣したマウスの変異型ASXL1遺伝子がノックインされ、該遺伝子が造血細胞で特異的に発現するノックインマウス。【選択図】なし
