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DRUG DELIVERY COMPOSITIONS AND USES THEREOF
专利权人:
Inc.;Dana-Farber Cancer Institute
发明人:
Michael Solomon Goldberg,Chun Gwon Park
申请号:
US16529189
公开号:
US20200031930A1
申请日:
2019.08.01
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Provided are drug delivery compositions and devices useful for the treatment and/or prevention of cancer and metastatic tumors. For example, a drug delivery device is provided that comprises a biodegradable scaffold carrying one or more anti-cancer therapeutic agents that activate the innate immune system (e.g., STING agonists) and/or the adaptive immune system (e.g., anti-PD-1 antibodies). The compositions and devices may include a cytokine (e.g., IL-15 superagonist). The drug delivery device can be implanted in the void volume of a resected tumor to prevent tumor regrowth and tumor metastasis. Also provided are methods of making the drug delivery compositions and devices as well as kits containing materials to provide the compositions and devices.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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