PROTEINES D'AFFINITE ET LEURS UTILISATIONS

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专利权人:

INC.;NECTAGEN

发明人:

SUDERMAN, RICHARD J.,CHAO, DAVID M.,RICE, DAREN

申请号：

CA2957820

公开号：

CA2957820A1

申请日:

2015.08.24

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

In general, the invention features a novel CBM32 - derived affinity scaffold. In certain embodiments, the scaffold comprises two types of regions: constant regions (CRs) and variable loop regions (VLRs) as depicted in the structure in FIGURE 1. We have discovered that the CRs provide structural features that enable overall conformational stability while the intervening sequences corresponding to VLRs tolerate amino acid sequence randomization.

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中国工程科技知识中心

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