PROBLEM TO BE SOLVED: To provide compositions and methods for promoting the formation, proliferation and recruitment of TR1 cells and/or Breg cells, effective for treating or preventing a viral infection or an autoimmune disorder such as multiple sclerosis and diabetes.SOLUTION: A complex comprises a nanoparticle and disease-relevant antigen-MHCII complexes. The nanoparticle has a diameter selected from the group consisting of: a diameter from about 1 nm to about 100 nm； a diameter from about 1 nm to about 50 nm； a diameter from about 1 nm to about 20 nm； and a diameter from about 5 nm to about 100 nm. The ratio of the number of antigen-MHCII complexes to the number of nanoparticles is from about 10:1 to about 1000:1. The nanoparticle is non-liposomal and has a core, preferably a gold or iron oxide core. A method for making iron oxide nanoparticles comprises thermally decomposing iron acetyl acetonate.SELECTED DRAWING: Figure 3BCOPYRIGHT: (C)2019,JPO&INPIT【課題】ウイルス感染又は、糖尿病、多発性硬化症等の自己免疫障害の治療又は予防に有効な、TR1細胞及び/又はBreg細胞の形成、増殖、及び動員を促進するための組成物及び方法の提供。【解決手段】ナノ粒子と疾患に関連する抗原-MHCII複合体とを含む複合体であって、該ナノ粒子が、約1nm～約100nm；約1nm～約50nm；または約1nm～約20nmもしくは約5nm～約100nmの群から選択される直径を有し、かつ抗原-MHCII複合体とナノ粒子との数の比率が約10:1～約1000:1である、複合体。前記ナノ粒子が、非リポソーム性であり、金もしくは酸化鉄のコアを有することが好ましい。さらに、酸化鉄ナノ粒子を作製するための方法として、鉄アセチルアセトネートを熱分解する工程を含む。【選択図】図３Ｂ
