GUSTAVO F. DONCEL,KEYKAVOUS PARANG,HITESH KUMAR AGRAWAL
申请号：
BRPI0813709
公开号：
BRPI0813709A2
申请日:
2008.07.09
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/AIDS.
