GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
AXTEN, Jeffrey,CHEUNG, Mui,DEMARTINO, Michael P.,EIDAM, Hilary Schenck,KETHIRI, Raghava Reddy,KALITA, Biswajil
申请号：
IBIB2017/053372
公开号：
WO2017/212425A1
申请日:
2017.06.07
申请国别(地区):
IB
年份:
2017
代理人:
摘要：
The invention is directed to substituted piperidine derivatives. Specifically, the invention is directed to compounds according to Formula IIII: wherein A, B, X, Y, L1, L2, L3, R1, R2, R3, R4, R5, R6, R9, z2, z4, z5, and z6 are as defined herein, and salts thereof. The compounds of the invention are inhibitors of the ATF4 pathway and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease, spinal cord injury, traumatic brain injury, ischemic stroke, stroke, diabetes, Parkinson disease, Huntington's disease, Creutzfeldt-Jakob Disease, and related prion diseases, progressive supranuclear palsy, amyotrophic lateral sclerosis, myocardial infarction, cardiovascular disease, inflammation, fibrosis, chronic and acute diseases of the liver, chronic and acute diseases of the lung, chronic and acute diseases of the kidney, chronic traumatic encephalopathy (CTE), neurodegeneration, dementia, cognitive impairment, atherosclerosis, ocular diseases, arrhythmias, in organ transplantation and in the transportation of organs for transplantation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.L'invention concerne des dérivés de pipéridine substitués. Notamment, l'invention concerne des composés selon la formule III : dans laquelle A, B, X, Y, L 1 , L 2 , L 3 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 9 , z 2 , z 4 , z 5 , et z 6 sont tels que définis dams la description, et leurs sels. Les composés de l'invention sont des inhibiteurs de la voie ATF4 et peuvent être utiles dans le traitement du cancer, de syndromes précancéreux et de maladies associées à des voi
