The present application discloses a nanoparticle comprising compounds of the formula A-B-C(-D), wherein A designates an anchoring moiety having self-organizing properties in relation to the nanoparticle B designates a cleavable linker C designates an anionic moiety having a net charge of at least &minus2 at pH 6.0 and D, which is optional, designates a polymer moiety which induces long circulating properties of the nanoparticle in mammalian tissue and wherein the average net charge of the compounds is at least &minus1 at pH 6.0. The application also discloses the individual compounds of the formula A-B-C(-D) as well as a drug delivery system comprising the self-organized nanoparticle having included in the interior thereof one or more pharmaceutically active agents and/or diagnostically relevant species, and a method of treating a cancerous or inflammatory condition in a mammal, involving the administration of the drug delivery system to the mammal.
