HYPROMELLOSE ACETATE SUCCINATE POWDERS HAVING EXCELLENT CLARITY AND COLOR OF SOLUTION AND PRODUCTION METHOD THEREOF, AS WELL AS EACH PRODUCTION METHOD OF SOLID DISPERSION COMPOSITION, COATING COMPOSITION, DRUG-CONTAINING PARTICLES, AND SOLID PREPARATIONS
PROBLEM TO BE SOLVED: To provide HPMCAS powders having high solubility at the time of dissolving in a solvent and capable of suppressing generation of undissolved materials, and to provide production methods thereof.SOLUTION: Provided is a hypromellose acetate succinate powder having the mean value of the ratio (L/D) of a maximum diameter (L) and a minimum diameter (D) of 2.0 to 3.0. Also provided is a production method of hypromellose acetate succinate at least comprising a dissolution step of dissolving hypromellose in a solvent, an esterification step of reacting succinic anhydride and acetic anhydride to the dissolved hypromellose in the presence of a catalyst to obtain a reaction solution, and a precipitation step of precipitating hypromellose acetate succinate by mixing the reaction solution and water, wherein the viscosity of the reaction solution before mixing with water is 100 to 200 Pa s.SELECTED DRAWING: None【課題】溶媒に溶解させた際に高い溶解性を有し、未溶解物の発生を抑えることができるＨＰＭＣＡＳ粉末及びその製造方法等を提供する。【解決手段】最大径（Ｌ）と最小径（Ｄ）の比（Ｌ／Ｄ）の平均値が、２．０～３．０であるヒプロメロース酢酸エステルコハク酸エステル粉末を提供する。また、ヒプロメロースを溶媒に溶解する溶解工程と、触媒存在下、前記溶解されたヒプロメロースに無水コハク酸及び無水酢酸を反応させて反応液を得るエステル化工程と、前記反応液と水を混合してヒプロメロース酢酸エステルコハク酸エステルを析出させる析出工程であって、前記水と混合する前の前記反応液の粘度が１００～２００Ｐａ・ｓである析出工程とを少なくとも含むヒプロメロース酢酸エステルコハク酸エステルの製造方法を提供する。【選択図】なし
