Systems, methods and devices are provided for use in a negative pressure wound therapy system for healing a wound in a patient. Various aspects may include an ester-based material adapted to be directly applied to the wound, such as a smooth muscle fistula, without substantially damaging tissue in the wound during dressing changes. The ester-based material may have an affinity for the wound bed surface and/or wound fluid. In addition, various aspects may include a device adapted to close the wound, such as a smooth muscle fistula.
