TECHNION RESEARCH &； DEVELOPMENT FOUNDATION LIMITED
发明人:
Yoav D. LIVNEY,Adi SEIFERT
申请号：
US16645892
公开号：
US20200276321A1
申请日:
2018.09.09
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein is a particle made of a protein covalently bound to a prebiotic carbohydrate, thereby forming a conjugate, wherein at least two said conjugates are covalently crosslinked via their carbohydrate units (e.g. by a phospho-di-ester bond). The said particle may be used for selectively promoting probiotic bacteria growth in the colon and may be used to deliver additional probiotic growth factors, or other bioactives and drugs to the colon. Furthermore, provided herein are methods for preparing the particle, and for delivering a substance bound to, or entrapped within the particle, into the gastrointestinal tract of a subject in need thereof.
