Using G-protein idol United Shou Body He Xiang Off Group closes Wu Sieve Election method农业专利-农业学术服务平台

专利权人:: The General Hospital Corporation;Chugai Seiyaku Kabushiki Kaisha;總醫院有限公司;中外制药株式会社;总医院有限公司;中外製藥株式會社

发明人:: GARDELLA, Thomas, J.,托马斯．J．加德拉,托馬斯．J．加德拉,POTTS, John, T.,约翰．T．波茨,約翰．T．波茨,SHIMIZU, Masaru,清水胜,清水勝,ICHIKAWA, Fumihiko,市川文彦,市川文彥,JUPPNER, Harald,哈拉尔德．朱佩内尔,哈拉爾德．朱佩內爾,OKAZAKI, Makoto,冈崎诚,岡崎誠,托马斯.J.加德拉,托馬斯.J.加德拉,约翰.T.波茨,約翰.T.波茨,哈拉尔德.朱佩内尔,哈拉爾德.朱佩內爾

摘要：: This Hair is bright to relate to the use of G-protein idol United Shou Body He Xiang Off Group closes Wu Sieve Election method, it is provided with what GPCR Sieve Election method, its base what Yi Xia Hair Now: When non-Knot close what G Dan Bai Time Shou Body swash glandular hormone Shou Body) Pro by Move Elixirs Right what GPCR(such as first Like He Qi Inter of Li With swash Move Elixirs You Xiao Time Inter Long Du You Off , Er With its Drug object Move Li Learn Te No Off. The bright It of this Hair provides the polypeptide in the source PTH and PTHrP Come.本發明涉及利用G蛋白偶聯受體和相關組合物的篩選方法，其提供了用於GPCR的篩選方法，其基於以下發現：當未結合於G蛋白時，受體激動劑對於GPCR（如甲狀旁腺激素受體）的親和力與其間激動劑有效的時間長度有關，而與它的藥物動力學特性無關。本發明還提供了PTH和PTHrP來源的多肽。