A denture cleaning wipe is a sheet made of a flexible material with a gripping surface opposite a cleaning surface. A first finger pocket and a second finger pocket are each coupled to the gripping surface so that a first portion of an outer edge of the first and second finger pockets are coupled to the sheet and a second portion of the outer edge of the first and second finger pockets are detached from the sheet defining entrances into the first and second finger pockets. The first finger pocket and the second finger pocket are spaced apart and oriented so that the entrances are facing each other.