Disclosed are methods, compositions and formulations for treating or preventing hypercalciuria thereby reducing the risk of nephrolithiasis and normalizing urine chemistry and composition. The method includes administering vitamin K2 in a medicinal or nutritional composition, preferably without calcium, optionally in combination with a therapeutic dose of one or more selected from the group consisting of: a citrate salt, magnesium oxide, a bicarbonate salt and vitamin B6.本揭示為治療或預防高尿鈣症的方法、組成物及調配物，藉此降低腎結石之風險及正常化尿液化學及組成。該方法包括於醫藥組成物或營養組成物中投予維生素K2，以不含鈣為佳，視需要組合治療劑量之選自於由下列所組成的組群中之一或多者：檸檬酸鹽、氧化鎂、碳酸氫鹽、及維生素B6。
