A compound according to Formula Ia: wherein L1, G, and R1 are as decribed herein. The present invention relates to novel compounds according to Formula I that antagonize GPR84, a G-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions (for example inflammatory bowel diseases (IBD), rheumatoid arthritis, vasculitis, lung diseases (e.g. chronic obstructive pulmonary disease (COPD) and lung interstitial diseases (e.g. idiopathic pulmonary fibrosis (IPF))), neuroinflammatory conditions, infectious diseases, autoimmune diseases, endocrine and/or metabolic diseases, and/or diseases involving impairment of immune cell functions by administering a compound of the invention.本發明係關於一種如式Ia之化合物：其中L1、G及R1係如本文中所描述。本發明係關於一種會拮抗GPR84(係一種與發炎病症有關之G蛋白質偶合受體)之新穎之式I化合物，及製造此等新穎化合物之方法，包含此等化合物之醫藥組成物，及透過投與本發明化合物防止及/或治療發炎病症(例如發炎性腸病(IBD)、類風濕性關節炎、血管炎、肺病(例如慢性阻塞性肺病(COPD)及間質性肺病(例如，特發性肺纖維化(IPF)))、神經發炎病症、傳染性疾病、自體免疫疾病、內分泌及/或代謝疾病、及/或與免疫細胞功能受損有關之疾病之方法。
