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VACCINE
专利权人:
АФФИРИС АГ (AT)
发明人:
ШТАФЛЕР Гюнтер (AT),ЛЮРС Петра (AT),МАИРХОФЕР Андреас (AT),МАТТНЕР Франк (AT),ШМИДТ Вальтер (AT),ДОЛИШКА Андреа (AT)
申请号:
RU2012106506/10
公开号:
RU2012106506A
申请日:
2010.07.23
申请国别(地区):
RU
年份:
2013
代理人:
摘要:
1. A vaccine comprising a peptide associated with a pharmaceutically acceptable carrier with the amino acid sequence described by the formula for the treatment and / or prevention of a physical disorder associated with a reninactivable angiotensin system, where X is G or D, X is A, P, M, G or R , X represents G, A, H or V, X represents S, A, D or Y, X represents A, D, H, S, N or I, X represents A, L or F, where m, n and o are independently equal to 0 or 1 from each other, provided that when 0 is 0, m and n are 0, and when n p clearly 0, m is 0, and wherein said peptide is not a peptide DRVYIHPF.2. The vaccine according to claim 1, characterized in that the peptide is selected from the group consisting of GRVYIHPF, DGVYIHPF, DAAYIHPF, DRAAIHPF, DRAYAHPF, DPGYIHPF, DMVSIHPF, DRGAIHPF, DRGYDHPF, DRHYDHPF, DRHYDHPF, DRHYDHPF. The vaccine according to claim 1, characterized in that at least one cysteine residue is attached to the N-terminus of the amino acid sequence corresponding to Formula I.4. The vaccine according to claim 1, characterized in that the carrier is a protein carrier. A vaccine according to claim 4, characterized in that the protein carrier is selected from the group consisting of fissurella hemocyanin, tetanus toxoid and diphtheria toxin. The vaccine according to claim 1, characterized in that the compound is mixed with an adjuvant, preferably adsorbed on alum. A vaccine according to any one of claims 1 to 6, characterized in that the physical disorder associated with the reninactivated angiotensin system is selected from the group comprising arterial hypertension, stroke, myocardial infarction, renal failure, congestive heart failure, atherosclerosis, vascular damage, hemorrhage in the retina and out1. Вакцина, включающая пептид, связанный с фармацевтически приемлемым носителем, с аминокислотной последовательностью, описываемой формулойдля лечения и/или профилактики физического расстройства, связанного с ренинактивируемой ангиотензиновой системой, гдеX
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