A transdermal dosage unit containing drug comprising: (a) an impermeable backing layer to a drug to be administered transdermally (B) a first polymeric adhesive matrix comprising an acrylic adhesive, in contact with the derefuerzo layer which has dispersed therein the drug and having a first initial rate of drug administracióndel (C) a second polymeric adhesive matrix comprising a silicone adhesive or depoliisobutileno adhesive in contact with said first polymeric adhesive matrix in its interior having dispersed elfármaco and having a second initial rate of delivery of the drug, wherein said second velocidadinicial administration is different from said first initial rate of delivery, and wherein the polymeric adhesive primeramatriz administered the drug more slowly than said second adhesivapolimérica matrix and (d) a release liner in contact with the second polymeric adhesive matrix wherein the drug is selected from the group consisting of: cardiovascular drug, an androgenic steroid, unestrógeno, a progestational agent, a sedative, a sleeping pill, an analgesic, an anesthetic, a agenteantiansiedad, a nutritional agent, an antiinflammatory agent, an antihistamine , a miotic, one agentedermatológico, an antispasmodic, an antidepressant, an anticancer drug, an antidiabetic drug, unagente antiestrogen, an anti-hormonal drug, an anti-infective agent, an anti-allergenic agent, a agenteantipirético, an antimigraine agent, a tranquilizer and antipsychotic agent.Una unidad de dosificación transdérmica que contiene fármaco que comprende: (a) una capa de refuerzo impermeable a un fármaco a administrar por vía transdérmica (b) una primera matriz adhesiva polimérica que comprende un adhesivo acrílico, en contacto con la capa derefuerzo, que en su interior tiene disperso el fármaco y que tiene una primera velocidad inicial de administracióndel fármaco (c) una segunda matriz adhesiva polimérica que comprende un adhesivo de silicona o un adhesivo depoliisobutileno, en contacto con
