Birgit Bramlage;Akin Akinc;Maria Frank-Kamenetsky;Kevin Fitzgerald;Pamela Tan;Victor E. Kotelianski
发明人:
Pamela Tan,Birgit Bramlage,Maria Frank-Kamenetsky,Kevin Fitzgerald,Akin Akinc,Victor E. Kotelianski
申请号：
US13472438
公开号：
US08809292B2
申请日:
2012.05.15
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier and method for treating diseases caused by PCSK9 gene expression.
