The present invention relates to the control of pest insects. More specifically the invention relates to the identification, isolation and characterization of polypeptides for use in the control of pest insects. The invention thus provides insect-controlling peptides. Also provided are nucleic acids encoding such insect-controlling polypeptides and host cells and plants expressing such polypeptides. The present invention further provides compositions comprising polypeptides which are useful to combat crop pest insects in agriculture, insects which are pests for humans and animals, and house-hold pest insects. Also provided are methods for combating such pest insects.